Human Neutrophils Channels and Blocks Calcium Entry into Multiple Transient Receptor Potential Cytoskeletal Reorganization Internalizes
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Chemico-genetic identification of drebrin as a regulator of calcium responses.
Store-operated calcium channels are plasma membrane Ca(2+) channels that are activated by depletion of intracellular Ca(2+) stores, resulting in an increase in intracellular Ca(2+) concentration, which is maintained for prolonged periods in some cell types. Increases in intracellular Ca(2+) concentration serve as signals that activate a number of cellular processes, however, little is known abo...
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Human polymorphonuclear neutrophil (PMN) responses to G protein-coupled chemoattractants are highly dependent upon store-operated Ca(2+) entry (SOCE). Recent research suggests that SOCE currents can be mediated by a variety of related channel proteins of the transient receptor potential superfamily. SOCE has been regarded as a specific response to depletion of cell calcium stores. We hypothesiz...
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Cytosolic calcium signals occur in response to diverse stimuli and regulate a range of cellular processes [1]. In most non-excitable cells, increases in cytosolic calcium are brought about by its release from the endoplasmic reticulum (ER). The principal release channels are inositol 1,4,5-trisphosphate (IP3) receptors and ryanodine receptors, although other calcium channels may participate [1]...
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The selectin family of molecules (L-, P-, and E-selectin) mediates adhesive interactions between leukocytes and endothelial cells required for recruitment of leukocytes to inflammatory sites. Soluble E-selectin levels are elevated in inflammatory diseases and act to promote neutrophil beta(2)-integrin-mediated adhesion by prolonging Ca(2+) mobilization. Although soluble E-selectin alone was una...
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BACKGROUND The engagement of the T cell receptor results in actin cytoskeletal reorganization at the immune synapse (IS) and the triggering of biochemical signaling cascades leading to gene regulation and, ultimately, cellular activation. Recent studies have identified the WAVE family of proteins as critical mediators of Rac1-induced actin reorganization in other cell types. However, whether th...
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تاریخ انتشار 2003